LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome
L. Bozal-Basterra, M. Gonzalez-Santamarta, A. Bermejo-Arteagabeitia, C. Da Fonseca, O. Pampliega, R. Andrade, N. Martin-Martin, T. C. Branon, A. Y. Ting, A. Carracedo, J. A. Rodriguez, F. Elortza, J. D. Sutherland, R. Barrio
The paper identifies LUZP1 as a regulator of primary cilia and actin cytoskeleton, showing its role in Townes-Brocks Syndrome through interactions with SALL1 and effects on ciliogenesis and Sonic Hedgehog signaling.
bioRxiv · Jul 31, 2019Cell Biology