Author

A. Carracedo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3

Frequent Co-Authors

A. M. Aransay· 3 shared A. R. Cortazar· 3 shared R. Barrio· 3 shared F. Elortza· 2 shared I. Hermanova· 2 shared J. D. Sutherland· 2 shared N. Martin-Martin· 2 shared U. Mayor· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

A. M. Aransay

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Author profile →

8 papers

Recent·Most cited

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway

J. Pencik, C. Philippe, M. Schlederer, M. Pecoraro, S. Grund-Groeschke, W. J. Li, A. Tracz, I. Heidegger, S. Lagger, K. Trachtova, M. Oberhuber, E. Heitzer, O. Osman, H. A. Neubauer, B. Wingelhofer, , C. McKinney

This study identifies STAT3's role in restricting prostate cancer metastasis and antiandrogen resistance by regulating the LKB1/CREB signaling pathway in mouse models and human patients.

bioRxiv · Aug 25, 2022 · PreprintCancer Biology

Identification of a minimal biomarker profile in head-and-neck squamous cell carcinoma tumors

L. Sanchez-Diaz, L. E. Navas, E. Suarez-Martinez, B. Felipe-Abrio, C. Fernandez-Rozadilla, E. M. Verdugo-Sivianes, M. A. Celis-Romero, M. Chaves-Conde, M.-D. Chiara, Y. Garcia-Mayea, M. E. LLeonart, J. M. Garcia-Heredia, S. Munoz-Galvan, A. Carracedo, J. P. Rodrigo, A. Carnero

The paper identifies three genes, WDR66, SERPINH1, and ZNF622, as a minimal biomarker signature for predicting prognosis in head-and-neck squamous cell carcinoma.

bioRxiv · Nov 12, 2021 · PreprintCancer Biology

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

S. M. Davidson, J. E. Heyman, J. P. O'Brien, A. C. Liu, D. R. Schmidt, W. J. Israelsen, T. L. Dayton, R. Sehgal, R. Bronson, E. Freinkman, H. Mak, S. Malstrom, G. Bellinger, A. Carracedo, P. P. Pandolfi, , M. G. Vander Heiden

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

bioRxiv · May 9, 2021Cancer Biology

Identification of proximal SUMO-dependent interactors using SUMO-ID

O. Barroso-Gomila, F. Trulsson, V. Muratore, I. Canosa, L. Merino-Cacho, A. R. Cortazar, C. Perez, M. Azkargorta, I. Iloro, A. Carracedo, A. M. Aransay, F. Elortza, U. Mayor, A. C. O. Vertegaal, R. Barrio, J. D. Sutherland

This study introduces SUMO-ID, a method to identify SUMO-dependent protein interactors using TurboID and protein-fragment complementation, revealing novel interactions related to transcription, DNA damage, and stress response.

bioRxiv · Dec 28, 2020Biochemistry

Stromal Oncostatin M axis promotes breast cancer progression

A. M. Araujo, A. Abaurrea, P. Azcoaga, J. I. Lopez-Velazco, R. Rezola, I. Osorio-Querejeta, F. Valdes-Mora, J. M. Flores, L. Jenkins, P. Fernandez-Nogueira, N. Ferrari, N. Martin-Martin, A. Tzankov, S. Eppenberger-Castori, I. Alvarez-Lopez, , C. H. Lawrie

This study identifies the stromal OSM:OSMR axis as a key driver of breast cancer progression by reprogramming the tumor microenvironment.

bioRxiv · Oct 30, 2020Cancer Biology

USP29 is a novel non-canonical Hypoxia Inducible Factor-α activator

A. S. Schober, I. Martin-Barros, T. Martin-Mateos, E. Perez-Andres, O. Carlevaris, S. Pozo, A. R. Cortazar, A. M. Aransay, A. Carracedo, U. Mayor, V. See, E. Berra

This study identifies USP29 as a non-canonical activator of HIF-α that stabilizes HIF-1 and HIF-2 independently of oxygen, PHD, and pVHL, and correlates with disease progression in prostate cancer.

bioRxiv · Feb 20, 2020 · PreprintCell Biology

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome

L. Bozal-Basterra, M. Gonzalez-Santamarta, A. Bermejo-Arteagabeitia, C. Da Fonseca, O. Pampliega, R. Andrade, N. Martin-Martin, T. C. Branon, A. Y. Ting, A. Carracedo, J. A. Rodriguez, F. Elortza, J. D. Sutherland, R. Barrio

The paper identifies LUZP1 as a regulator of primary cilia and actin cytoskeleton, showing its role in Townes-Brocks Syndrome through interactions with SALL1 and effects on ciliogenesis and Sonic Hedgehog signaling.

bioRxiv · Jul 31, 2019Cell Biology

Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer.

L. Valcarcel, A. Macchia, N. Martin, A. R. Cortazar, A. Schaub, M. Pujana, S. Fernandez, I. Lacasa, A. Santos, A. Loizaga, M. Unda, I. Hermanova, I. Astobiza, M. Graupera, J. Starkova, , V. Torrano

The paper identifies MITF as a tumor suppressor in prostate cancer and reveals CRYAB as a direct target mediating its suppressive activity through integrative transcriptomic and clinical analysis.

bioRxiv · Aug 14, 2018Cancer Biology