A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection
Y. Ueki, M. Hadders, M. B. Weisser, I. Nasa, T. Gupta, E. T. Hertz, T. Kruse, G. Montoya, A. A. Jeyaprakash, A. Kettenbach, S. M. A. Lens, J. Nilsson
This study identifies a conserved binding pocket on PP2A-B56 essential for Sgo1 interaction and cohesion protection, showing that complex formation is not strictly required for cohesion protection.
bioRxiv · Dec 18, 2020Cell Biology