Author

A. Kettenbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

J. Nilsson· 6 shared I. Nasa· 4 shared B. Lopez-Mendez· 3 shared M. B. Weisser· 3 shared T. Kruse· 3 shared A. A. Jeyaprakash· 2 shared B. McEwan· 2 shared D. Garvanska· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersCell Biology

J. Nilsson

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Author profile →

6 papers

Recent·Most cited

Substrate recognition principles for the PP2A-B55 protein phosphatase

T. Kruse, D. Garvanska, J. K. Varga, W. Garland, B. McEwan, J. Hein, M. B. Weisser, I. B. Puy, C. Chan, P. S. Parrila, B. Lopez-Mendez, A. A. Jeyaprakash, O. Schueler-Furman, T. H. Jensen, A. Kettenbach, J. Nilsson

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

bioRxiv · Feb 10, 2024Cell Biology

Global substrate identification and high throughput in vitro dephosphorylation reactions uncover PP1 and PP2A-B55 specificity principles

J. B. Hein, H. T. Nguyen, D. Garvanska, I. Nasa, Y. Feng, B. Lopez-Mendez, N. E. Davey, A. Kettenbach, P. M. Fordyce, J. Nilsson

The paper develops an in vitro assay to determine phosphatase specificity and applies it to study mitotic exit, revealing substrate preferences and biological relevance.

bioRxiv · May 14, 2023 · PreprintCell Biology

Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

G. Vit, J. Duro, G. Rajendraprasad, E. P. Hertz, L. Holland, M. B. Weisser, B. McEwan, B. Lopez-Mendez, G. Montoya, N. Mailand, K. Maeda, A. Kettenbach, J. Nilsson

This study challenges previous claims that iHAP1 and DT-061 target PP2A-B56 complexes, showing instead that they exert toxicity through microtubule disruption and ER/Golgi disruption, respectively.

bioRxiv · Jul 8, 2021Cell Biology

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

S. M. Ambjoern, J. P. Duxin, E. P. Hertz, I. Nasa, J. Duro, T. Kruse, B. Lopez Mendez, B. Rymarczyk, L. E. Cressey, T. Hansen, A. Kettenbach, V. H. Oestergaard, M. Lisby, J. Nilsson

This study identifies the BRCA2-PP2A-B56 complex as essential for efficient DNA repair by homologous recombination and shows that cancer mutations disrupt this interaction, increasing sensitivity to PARP inhibition.

bioRxiv · Apr 10, 2021Cell Biology

A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection

Y. Ueki, M. Hadders, M. B. Weisser, I. Nasa, T. Gupta, E. T. Hertz, T. Kruse, G. Montoya, A. A. Jeyaprakash, A. Kettenbach, S. M. A. Lens, J. Nilsson

This study identifies a conserved binding pocket on PP2A-B56 essential for Sgo1 interaction and cohesion protection, showing that complex formation is not strictly required for cohesion protection.

bioRxiv · Dec 18, 2020Cell Biology

Coupling of Cdc20 inhibition and activation by BubR1

J. Hein, D. H. Garvanska, I. Nasa, A. Kettenbach, J. Nilsson

This study shows BubR1 has both inhibitory and activating roles in Cdc20, enabling dephosphorylation by PP2A-B56 in the MCC while preventing premature anaphase.

bioRxiv · Dec 18, 2020Cell Biology