Author

T. Kruse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Assay:cryo-EM· 1

Frequent Co-Authors

J. Nilsson· 6 shared A. Kettenbach· 3 shared A. A. Jeyaprakash· 2 shared B. Lopez-Mendez· 2 shared I. Nasa· 2 shared M. B. Weisser· 2 shared A. K. Overby· 1 shared A. Moliner Morro· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersCell Biology

J. Nilsson

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6 papers

Recent·Most cited

Substrate recognition principles for the PP2A-B55 protein phosphatase

T. Kruse, D. Garvanska, J. K. Varga, W. Garland, B. McEwan, J. Hein, M. B. Weisser, I. B. Puy, C. Chan, P. S. Parrila, B. Lopez-Mendez, A. A. Jeyaprakash, O. Schueler-Furman, T. H. Jensen, A. Kettenbach, J. Nilsson

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

bioRxiv · Feb 10, 2024Cell Biology

Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19

S. K. Padi, M. R. Vos, R. J. Godek, J. R. Fuller, T. Kruse, J. B. Hein, J. Nilsson, M. S. Kelker, R. Page, W. Peti

The paper reports cryo-EM structures of PP2A:B55 bound to phosphorylated ARPP19 and FAM122A, revealing distinct binding mechanisms and providing insights for therapeutic development.

bioRxiv · Aug 31, 2023Biochemistry

Separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

J. Nilsson, L. Wang, T. Kruse, B. Lopez-Mendez, Y. Zhang, C. Song, L. Zhu, B. Li, J. Fang, z. Lu, G. Zhang

This study shows that separating kinase and phosphatase activities in the Bub complex is essential for proper mitosis, as merging these functions leads to mitotic defects.

bioRxiv · Apr 11, 2022 · PreprintCell Biology

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

T. Kruse, C. Benz, D. H. Garvanska, R. Lindqvist, F. Mihalic, F. Coscia, R. Inturi, A. Sayadi, L. Simonetti, E. Nilsson, M. Ali, J. Kliche, A. Moliner Morro, A. Mund, E. Andersson, , Y. Ivarsson

The paper identifies coronavirus-host protein interaction motifs, revealing SARS-CoV-2 specific mechanisms and a peptide-based inhibitor that blocks infection.

bioRxiv · Apr 19, 2021Biochemistry

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

S. M. Ambjoern, J. P. Duxin, E. P. Hertz, I. Nasa, J. Duro, T. Kruse, B. Lopez Mendez, B. Rymarczyk, L. E. Cressey, T. Hansen, A. Kettenbach, V. H. Oestergaard, M. Lisby, J. Nilsson

This study identifies the BRCA2-PP2A-B56 complex as essential for efficient DNA repair by homologous recombination and shows that cancer mutations disrupt this interaction, increasing sensitivity to PARP inhibition.

bioRxiv · Apr 10, 2021Cell Biology

A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection

Y. Ueki, M. Hadders, M. B. Weisser, I. Nasa, T. Gupta, E. T. Hertz, T. Kruse, G. Montoya, A. A. Jeyaprakash, A. Kettenbach, S. M. A. Lens, J. Nilsson

This study identifies a conserved binding pocket on PP2A-B56 essential for Sgo1 interaction and cohesion protection, showing that complex formation is not strictly required for cohesion protection.

bioRxiv · Dec 18, 2020Cell Biology