Author

I. Nasa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Kettenbach· 4 shared J. Nilsson· 4 shared A. N. Kettenbach· 2 shared T. Kruse· 2 shared A. A. Jeyaprakash· 1 shared B. Lopez Mendez· 1 shared B. Lopez-Mendez· 1 shared B. Rymarczyk· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

A. Kettenbach

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Author profile →

6 papers

Recent·Most cited

Global substrate identification and high throughput in vitro dephosphorylation reactions uncover PP1 and PP2A-B55 specificity principles

J. B. Hein, H. T. Nguyen, D. Garvanska, I. Nasa, Y. Feng, B. Lopez-Mendez, N. E. Davey, A. Kettenbach, P. M. Fordyce, J. Nilsson

The paper develops an in vitro assay to determine phosphatase specificity and applies it to study mitotic exit, revealing substrate preferences and biological relevance.

bioRxiv · May 14, 2023 · PreprintCell Biology

Inducible protein degradation as a strategy to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells

N. C. Mariano, S. F. Rusin, I. Nasa, A. N. Kettenbach

The paper uses inducible protein degradation to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells and reveals its role in mitotic regulation.

bioRxiv · Mar 25, 2023Cell Biology

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

S. M. Ambjoern, J. P. Duxin, E. P. Hertz, I. Nasa, J. Duro, T. Kruse, B. Lopez Mendez, B. Rymarczyk, L. E. Cressey, T. Hansen, A. Kettenbach, V. H. Oestergaard, M. Lisby, J. Nilsson

This study identifies the BRCA2-PP2A-B56 complex as essential for efficient DNA repair by homologous recombination and shows that cancer mutations disrupt this interaction, increasing sensitivity to PARP inhibition.

bioRxiv · Apr 10, 2021Cell Biology

A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection

Y. Ueki, M. Hadders, M. B. Weisser, I. Nasa, T. Gupta, E. T. Hertz, T. Kruse, G. Montoya, A. A. Jeyaprakash, A. Kettenbach, S. M. A. Lens, J. Nilsson

This study identifies a conserved binding pocket on PP2A-B56 essential for Sgo1 interaction and cohesion protection, showing that complex formation is not strictly required for cohesion protection.

bioRxiv · Dec 18, 2020Cell Biology

Coupling of Cdc20 inhibition and activation by BubR1

J. Hein, D. H. Garvanska, I. Nasa, A. Kettenbach, J. Nilsson

This study shows BubR1 has both inhibitory and activating roles in Cdc20, enabling dephosphorylation by PP2A-B56 in the MCC while preventing premature anaphase.

bioRxiv · Dec 18, 2020Cell Biology

A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1

H. E. Opalko, I. Nasa, A. N. Kettenbach, J. B. Moseley

This study identifies how Cdr1/Nim1 kinase inhibits Wee1 to promote mitotic entry by phosphorylating specific serine residues in yeast.

bioRxiv · Oct 7, 2019Cell Biology