M. Hrabe de Angelis

This paper identifies two regulatory mechanisms, transcriptional and translational, by which TIS7 and SKMc15 control DLK1 levels, impacting adipogenesis and obesity resistance.

This paper describes a new mouse model with a KIT mutation that develops late-onset mammary tumors with high penetrance and lung metastasis.

This paper develops a scalable pig model for Duchenne muscular dystrophy by breeding DMD carriers, enabling large cohorts for disease mechanism studies and therapeutic testing.

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

This study shows that UCP1 deletion does not affect diet-induced obesity at thermoneutrality and introduces a novel UCP1-KO mouse model.

The study characterizes the Titan mouse as a model for metabolically unhealthy obesity and shows that dietary intervention improves its health and extends lifespan.