Author

M. Irondelle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

F. Bost· 2 shared V. Tiroille· 2 shared A. Baeri· 1 shared A. Carminati· 1 shared A. Mazzu· 1 shared A.-S. GAY· 1 shared B. DOLFI· 1 shared B. Mari· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

F. Bost

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

J. Contenti, Y. Guo, M. Larcher, L. Mirabal-Ortega, M. ROULEAU, M. Irondelle, V. Tiroille, A. Mazzu, V. Duranton-Tanneur, F. Pedeutour, I. Ben-Sahra, C. Lago, G. Leva, L. Tiberi, G. Robert, , N. M. Mazure

This study shows that Group 3 medulloblastoma cells rely on HIF-2 instead of HIF-1 for hypoxia adaptation, and inhibiting HIF-2 with metformin kills these cells more effectively than non-Group 3 cells.

bioRxiv · Oct 17, 2023Cancer Biology

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

S. Diazzi, A. Baeri, J. Fassy, M. Lecacheur, O. Marin-Bejar, C. Girard, L. Lefevre, C. Lacoux, M. Irondelle, C. Mounier, M. Truchi, M. Couralet, A. Carminati, I. Berestjuk, F. Larbret, , S. Tartare-Deckert

This study identifies the miR-143/-145 cluster as a driver of therapy-resistant mesenchymal-like phenotype in melanoma and shows that blocking its pro-fibrotic effects enhances MAPK inhibitor efficacy.

bioRxiv · Jul 2, 2021Cancer Biology

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFRsignaling

S. TORRINO, V. TIROILLE, B. DOLFI, M. DUFIES, C. HINAULT, L. BONESSO, S. DAGNINO, J. P. UHLER, M. IRONDELLE, A.-S. GAY, L. FLEURIOT, D. Debayle, S. LACAS-GERVAIS, M. CORMONT, T. BERTERO, , S. CLAVEL

This study shows UBTD1 regulates EGFR signaling by controlling ceramide levels and endolysosomal positioning through ubiquitination of ASAH1 and SQSTM1/p62.

bioRxiv · May 20, 2020Cell Biology