Author

S. Lacas-Gervais

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Animal Behavior & Cognition· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

D. Debayle· 3 shared A.-S. Gay· 2 shared E. C. Genin· 2 shared L. Fleuriot· 2 shared S. Bannwarth· 2 shared V. Paquis-Flucklinger· 2 shared A. Boulksibat· 1 shared A. Di Cicco· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

D. Debayle

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Author profile →

6 papers

Recent·Most cited

Mitochondria alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks

F. Eysert, P. F. Kinoshita, J. Lagarde, S. Lacas-Gervais, L. Xicota, G. Dorothee, M. Bottlaender, F. Checler, M.-C. Potier, M. Sarazin, M. Chami

The paper examines mitochondrial alterations in fibroblasts from Alzheimer's disease patients and links them to clinical hallmarks and cognitive decline.

bioRxiv · Dec 21, 2023 · PreprintCell Biology

Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A

S. Delhaye, M. Jarjat, A. Boulksibat, C. Sanchez, A. Tempio, A. Turtoi, M. Giorgi, S. Lacas-Gervais, G. Baj, C. Rovere, V. Trezza, M. Pellegrini, T. Maurin, E. Lalli, B. Bardoni

This study investigates the role of PDE2A in socio-cognitive deficits by analyzing Pde2a+/- mice, revealing microglia activation and AMPAR trafficking defects linked to cognitive impairments.

bioRxiv · Nov 6, 2023Animal Behavior & Cognition

Multiomics study of CHCHD10S59L-related disease reveals energy metabolism downregulation: OXPHOS and beta-oxidation deficiencies associated with lipids alterations

B. Madji Hounoum, R. Bellon, E. C. Genin, S. Bannwarth, A. Lefevre, L. Fleuriol, D. Debayle, A.-S. Gay, A. Petit-Paitel, S. Lacas-Gervais, H. Blasco, P. Edmond, V. Paquis-Flucklinger, J.-E. RICCI

This study identifies metabolic and lipid alterations in CHCHD10S59L-related disease, showing OXPHOS and beta-oxidation deficiencies and suggesting L-acetylcarnitine as a potential therapeutic.

bioRxiv · Jan 19, 2023 · PreprintCell Biology

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

M. Subra, M. Dezi, J. Bigay, S. Lacas-Gervais, A. Di Cicco, A. R. Dias Araujo, S. Abelanet, L. Fleuriot, D. Debayle, R. Gautier, A. Patel, F. Roussi, B. Antonny, D. Levy, B. Mesmin

This study shows that VAP-A's intrinsically disordered regions enable its versatile localization at different membrane contact sites by adjusting geometry to MCS organization and lifetime.

bioRxiv · May 13, 2022Cell Biology

SLP2/prohibitins aggregates and instability of the PHB complex are key elements in CHCHD10S59L-related disease

E. C. GENIN, S. Bannwarth, B. Ropert, A. Mauri-Crouzet, F. Lespinasse, G. Auge, K. Fragaki, C. Cochaud, S. Lacas-Gervais, V. Paquis-Flucklinger

The paper identifies SLP2/prohibitin aggregates and PHB complex instability as key factors in CHCHD10S59L-related disease, leading to mitochondrial dysfunction and apoptosis.

bioRxiv · May 31, 2021 · PreprintPathology

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFRsignaling

S. TORRINO, V. TIROILLE, B. DOLFI, M. DUFIES, C. HINAULT, L. BONESSO, S. DAGNINO, J. P. UHLER, M. IRONDELLE, A.-S. GAY, L. FLEURIOT, D. Debayle, S. LACAS-GERVAIS, M. CORMONT, T. BERTERO, , S. CLAVEL

This study shows UBTD1 regulates EGFR signaling by controlling ceramide levels and endolysosomal positioning through ubiquitination of ASAH1 and SQSTM1/p62.

bioRxiv · May 20, 2020Cell Biology