M. J. Federle

Rgg2/Rgg3 quorum sensing is a determinant of Streptococcus pyogenes-host interactions in a murine intact skin infection model

This study shows that the Rgg2/Rgg3 quorum sensing system is essential for Streptococcus pyogenes to establish and maintain skin infections in a mouse model.

The ComRS-SigX pathway regulates natural transformation in Streptococcus ferus

This study identifies the ComRS-SigX pathway in Streptococcus ferus as the system regulating natural transformation, showing it uses a XIP peptide and requires comR and sigX orthologs, enabling genetic manipulation of this species.

Quorum sensing regulation of a major facilitator superfamily transporter affects multiple streptococcal virulence factors

This study shows that a quorum sensing-regulated MFS transporter in Streptococcus pyogenes affects virulence factor expression and aminoglycoside sensitivity.

The proteomic and transcriptomic landscapes altered by Rgg2/3 activity in Streptococcus pyogenes

This study investigates how Rgg2/3 quorum sensing affects the transcriptome and proteome of Streptococcus pyogenes under induced or disrupted conditions, revealing stress responses linked to the stringent response.

The Atypical Antipsychotic Quetiapine Induces Multiple Antibiotic Resistance in Escherichia coli

This study shows that quetiapine exposure increases antibiotic resistance in E. coli by inducing marR mutations and altering gene expression.

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

This study identifies PplD as a de-N-acetylase that modifies the cell wall linkage unit of streptococcal rhamnopolysaccharides, enhancing resistance to host antimicrobial proteins.

A Streptococcus quorum sensing system enables suppression of innate immunity

This study shows that quorum sensing in Streptococcus pyogenes suppresses macrophage inflammatory responses by producing a QS-regulated factor.

Colonization of the murine oropharynx by Streptococcus pyogenes is governed by the Rgg2/3 quorum sensing system

This study shows that the Rgg2/3 quorum sensing system in Streptococcus pyogenes is critical for colonization of the murine oropharynx, with deletion of the activator reducing colonization and the repressor increasing it.

Structural basis of Rgg protein binding to their regulatory pheromones and target DNA promoters

This study determines the structural basis of Rgg protein interactions with SHP pheromones and DNA promoters, revealing a new model of transcriptional regulation in streptococci.