J. C. Chang

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients

The paper identifies spatial interactions between NOS2, COX2, and T-effector cells in ER- breast cancer, linking these patterns to poor patient outcomes and suggesting potential therapeutic strategies.

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER- Breast Cancer

This study identifies NOS2 and COX2 as key spatial targets in ER- breast cancer that influence immune phenotypes and clinical outcomes through spatial analysis of tumor microenvironments.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

Interferon-gamma is Quintessential for NOS and COX Expression in ER- Breast Tumors that Lead to Poor Outcome

The paper shows IFN-gamma induces NOS2 and COX2 in ER-breast tumors, linked to poor outcomes, through spatial analysis of tumor microenvironments.

Quorum sensing regulation of a major facilitator superfamily transporter affects multiple streptococcal virulence factors

This study shows that a quorum sensing-regulated MFS transporter in Streptococcus pyogenes affects virulence factor expression and aminoglycoside sensitivity.

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

This study identifies PplD as a de-N-acetylase that modifies the cell wall linkage unit of streptococcal rhamnopolysaccharides, enhancing resistance to host antimicrobial proteins.

A Streptococcus quorum sensing system enables suppression of innate immunity

This study shows that quorum sensing in Streptococcus pyogenes suppresses macrophage inflammatory responses by producing a QS-regulated factor.

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

The paper identifies molecular mechanisms of neuroendocrine transformation in lung cancer using multi-omic analysis of tumors and clinical samples.

Integrated biophysical characterization of fibrillar collagen-based hydrogels

This paper characterizes the biophysical properties of collagen-based hydrogels using integrated methods, showing how modifications affect structure, mechanics, and transport.