Author

J. M. Tremblay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

C. B. Shoemaker· 3 shared J. Jaskiewicz· 2 shared S. Tzipori· 2 shared A. Manjula-Basavanna· 1 shared A. Sheoran· 1 shared A. Shrestha· 1 shared B. Muriuki· 1 shared C. Giem· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

C. B. Shoemaker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

D. J. Vance, S. Basir, C. L. Piazza, G. Willsey, H. M. E. Haque, J. M. Tremblay, M. J. Rudolph, B. Muriuki, L. A. Cavacini, D. D. Weis, C. B. Shoemaker, N. J. Mantis

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.

bioRxiv · Jan 23, 2024 · PreprintImmunology

Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies

M. Debatis, H. Danz, J. M. Tremblay, K. Gaspie, R. Kudej, V. Vigdorovich, N. Sather, J. Jaskiewicz, S. Tzipori, C. B. Shoemaker

This study compares the functional and structural stability of monomeric and multimeric camelid VHHs in vitro and in vivo, showing some VHHs can match the stability of conventional antibodies in the gut.

bioRxiv · May 15, 2023Bioengineering

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

I. Gelfat, Y. Aqeel, J. M. Tremblay, J. Jaskiewicz, A. Shrestha, J. N. Lee, S. Hu, X. Qian, L. Magoun, A. Sheoran, D. Bedenice, C. Giem, A. Manjula-Basavanna, M. S. Osbourne, S. Tzipori, , N. S. Joshi

The paper develops VHH-based therapeutics displayed on probiotic E. coli Nissle 1917 to target enteric pathogens, showing they can bind and neutralize virulence factors.

bioRxiv · Jun 18, 2021Microbiology