Author

M. J. Sousa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

B. Castro· 2 shared F. Mendes· 2 shared S. Chaves· 2 shared A. Devin· 1 shared A. Ferreira· 1 shared A. Lopes· 1 shared A. P. Silva· 1 shared A. Preto· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

B. Castro

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The antifungal activity of cymoxanil is associated with proton pump inhibition and disruption of plasma membrane potential

F. Mendes, H. Meyer, L. Amaral, B. Castro, M. Schuldiner, M. J. Sousa, S. Chaves

This study investigates the antifungal mechanism of cymoxanil, finding it disrupts plasma membrane potential and inhibits proton pumps in yeast, suggesting a mode of action involving membrane transport and acidification.

bioRxiv · Mar 1, 2024 · PreprintCell Biology

The widely used cymoxanil fungicide impairs respiration in Saccharomyces cerevisiae via cytochrome c oxidase inhibition

F. Mendes, C. Pereira, T. Vieira, M. Pinto, B. Castro, S. Sousa, M. J. Sousa, A. Devin, S. Chaves

This study investigates how the fungicide cymoxanil impairs respiration in yeast by inhibiting cytochrome c oxidase.

bioRxiv · Feb 29, 2024 · PreprintBiochemistry

Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer

A. R. Bras, A. Lopes, N. Mendes, P. J. Costa, A. Ferreira, S. Granja, A. P. Silva, F. Tortosa, F. Baltazar, F. Gartner, M. J. Sousa, A. Valente, A. Preto

This study identifies a ruthenium compound, PMC79, that selectively inhibits KRAS mutations in colorectal cancer and enhances chemotherapy efficacy.

bioRxiv · Aug 9, 2023 · PreprintPharmacology & Toxicology