C. Pereira

The widely used cymoxanil fungicide impairs respiration in Saccharomyces cerevisiae via cytochrome c oxidase inhibition

This study investigates how the fungicide cymoxanil impairs respiration in yeast by inhibiting cytochrome c oxidase.

Structural and functional characterization of the NF-κB-targeting toxin AIP56 from Photobacterium damselae subsp. piscicida reveals a novel mechanism for membrane interaction and translocation

A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell derived cardiomyocytes

The paper develops a high-throughput 3D cardiac tissue assay using human iPSC-derived cardiomyocytes and fibroblasts to study mechanical and drug responses.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

This study identifies the exocyst complex as essential for constitutive secretion in mammalian cells by showing its role in carrier fusion and cargo delivery.

Thermopriming-associated proteome and sugar content responses in Pinus radiata embryogenic tissue

This study examines proteome and sugar content changes in Pinus radiata embryogenic tissue after heat treatment to understand thermopriming mechanisms.

A secreted NlpC/P60 endopeptidase from Photobacterium damselae subsp. piscicida cleaves the peptidoglycan of potentially competing bacteria

This paper identifies PnpA, a secreted NlpC/P60 endopeptidase from Photobacterium damselae subsp. piscicida, which cleaves the peptidoglycan of competing bacteria, suggesting a role in competitive advantage and nutrient acquisition.

Reprogramming of Human Cells to Pluripotency Induces CENP-A Chromatin Depletion

This study shows that reprogramming human cells to pluripotency reduces centromeric CENP-A levels, linking centromere dysfunction to stem cell aneuploidy.

CD44v6 expression is a novel predictive marker of therapy response and poor prognosis in gastric cancer patients

This study identifies CD44v6 expression as a predictor of therapy response and poor prognosis in gastric cancer patients, showing higher expression correlates with worse outcomes and benefit from chemotherapy.

Self-assembly of the RZZ complex into filaments drives kinetochore expansion in the absence of microtubule attachment

This study shows that the RZZ complex self-assembles into filaments to drive kinetochore expansion when microtubules are not attached, facilitating SAC signaling and chromosome segregation.