Author

M. J. Whittle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. P. Minton· 2 shared T. W. Bilverstone· 2 shared A. C. Lücke· 1 shared J. P. Steczynska· 1 shared M. L. Kelly· 1 shared M. M. Lister· 1 shared R. J. van Esveld· 1 shared S. J. Kerr· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

N. P. Minton

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2 papers

Recent·Most cited

A tale of two phage tails: Engineering the host range of bacteriophages infecting Clostridioides difficile

J. P. Steczynska, S. J. Kerr, M. L. Kelly, M. J. Whittle, T. W. Bilverstone, N. P. Minton

This paper expands the host range of C. difficile phages by engineering their tail fibre and associated chaperone genes using CRISPR/Cas9, resulting in a phage with broader host range and higher infection efficiency.

bioRxiv · Oct 16, 2023 · PreprintMicrobiology

A novel bacteriophage with broad host-range against Clostridioides difficile ribotype 078 elucidates the phage receptor.

M. J. Whittle, T. W. Bilverstone, R. J. van Esveld, A. C. Lücke, M. M. Lister, S. Kuehne, N. P. Minton

This study isolates four novel bacteriophages against C. difficile, identifies SlpA as the receptor for one phage with broad host-range activity against RT 078 strains, and suggests a strategy for developing a broad-spectrum phage cocktail.

bioRxiv · May 26, 2021Microbiology