Author

N. P. Minton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. J. Whittle· 2 shared S. Kuehne· 2 shared T. W. Bilverstone· 2 shared A. C. Lücke· 1 shared A. Donlan· 1 shared A.-K. Kotte· 1 shared C. Schwan· 1 shared J. L. Leslie· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

M. J. Whittle

Mutual co-authors in cluster

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4 papers

Recent·Most cited

A tale of two phage tails: Engineering the host range of bacteriophages infecting Clostridioides difficile

J. P. Steczynska, S. J. Kerr, M. L. Kelly, M. J. Whittle, T. W. Bilverstone, N. P. Minton

This paper expands the host range of C. difficile phages by engineering their tail fibre and associated chaperone genes using CRISPR/Cas9, resulting in a phage with broader host range and higher infection efficiency.

bioRxiv · Oct 16, 2023 · PreprintMicrobiology

Clostridioides difficile binary toxin binding component (CDTb) increases virulence in a hamster model

M. Simpson, T. Bilverstone, J. L. Leslie, A. Donlan, M. J. Uddin, W. Petri, N. Marin, C. Schwan, S. Kuehne, N. P. Minton, W. A. Petri

This study shows that CDTb, a component of C. difficile binary toxin, contributes to virulence by inducing inflammation and restoring virulence in a hamster model when expressed alone.

bioRxiv · Aug 3, 2021Microbiology

A novel bacteriophage with broad host-range against Clostridioides difficile ribotype 078 elucidates the phage receptor.

M. J. Whittle, T. W. Bilverstone, R. J. van Esveld, A. C. Lücke, M. M. Lister, S. Kuehne, N. P. Minton

This study isolates four novel bacteriophages against C. difficile, identifies SlpA as the receptor for one phage with broad host-range activity against RT 078 strains, and suggests a strategy for developing a broad-spectrum phage cocktail.

bioRxiv · May 26, 2021Microbiology

RNPP-type quorum sensing regulates solvent formation and sporulation in Clostridium acetobutylicum

A.-K. Kotte, O. Severn, Z. Bean, K. Schwarz, N. P. Minton, K. Winzer

This study identifies QssB quorum sensing as regulating solvent formation and sporulation in C. acetobutylicum through signaling peptides.

bioRxiv · Jan 28, 2020 · PreprintMicrobiology