M. K. Jolly

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

The paper identifies interconnected feedback loops among ESRP1, HAS2, and CD44 that regulate ZEB1 levels and drive epithelial-hybrid-mesenchymal transition in cancer, with ESRP1 as a key regulatory node.

This study uses hierarchical organization metrics to show that gene expression networks in IBC are more organized and linked to worse outcomes and epithelial traits in metastatic breast cancer.

This study shows Numb stabilizes a hybrid E/M phenotype by inhibiting Notch-driven full EMT, correlates with poor cancer survival, and predicts its role in tumor-initiation.

This paper examines the role of EMT and MET in metastasis, arguing that these processes are not binary and proposes alternative mechanisms beyond the traditional EMT-MET model.

This paper reviews how quantitative mathematical models have advanced understanding of epithelial-mesenchymal plasticity in tumors by explaining data, guiding experiments, and improving conceptual frameworks.

This review discusses molecular mechanisms enabling CTC clusters formation and their higher metastatic potential, using Inflammatory Breast Cancer as an example.

The paper uses experimental and theoretical approaches to evaluate two models of EMT dynamics, finding experimental evidence supporting the ternary chimera switch model over the cascading bistable switches model.