Author

K. E. Ware

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. A. Somarelli· 6 shared A. J. Armstrong· 4 shared M. K. Jolly· 4 shared W. C. Eward· 4 shared D. L. Corcoran· 3 shared M. U. Sheth· 3 shared S. Y. Kim· 3 shared B. C. Thomas· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersCancer Biology

J. A. Somarelli

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Author profile →

7 papers

Recent·Most cited

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

K. E. Ware, B. C. Thomas, P. Olawuni, M. U. Sheth, N. Hawkey, Y. M, B. C. Miller, K. Vietor, M. K. Jolly, S. Y. Kim, A. J. Armstrong, J. A. Somarelli

The paper identifies JAK/STAT signaling as a therapeutic target for Snail-induced enzalutamide-resistant prostate cancer through synthetic lethal screens and validation in a resistant cell model.

bioRxiv · Nov 15, 2022Cancer Biology

An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins

A. M. Blawas, K. E. Ware, E. Schmaltz, L. Zheng, J. Spruance, A. S. Allen, N. West, N. Devos, D. L. Corcoran, D. P. Nowacek, W. C. Eward, A. Fahlman, J. A. Somarelli

This study identifies ALOX5 upregulation during breath-holding in dolphins as a potential molecular mechanism for ischemic tolerance during diving.

bioRxiv · Jan 20, 2021Physiology

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

K. E. Ware, S. Gupta, J. Eng, G. Kemeny, B. J. Puviindran, W.-C. Foo, L. A. Crawford, R. G. Almquist, D. Runyambo, B. C. Thomas, M. U. Sheth, A. Agarwal, M. Pierobon, E. F. Petricoin, D. L. Corcoran, , J. Somarelli

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

bioRxiv · Apr 22, 2020 · PreprintCancer Biology

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms

M. K. Jolly, K. E. Ware, S. Xu, S. Gilja, S. Shetler, Y. Yang, X. Wang, G. Austin, D. Runyambo, A. J. Hish, S. Bartholf DeWitt, J. T. George, R. T. Kreulen, M.-K. Boss, A. L. Lazarides, , J. A. Somarelli

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

bioRxiv · Jan 10, 2019Cancer Biology

From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline

S. Rao, J. A. Somarelli, E. Altunel, L. E. Selmic, M. Byrum, M. U. Sheth, S. Cheng, K. E. Ware, S. Y. Kim, J. A. Prinz, N. Devos, D. L. Corcoran, A. Moseley, E. Soderblom, S. D. Hsu, W. C. Eward

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.

bioRxiv · Jan 10, 2019Cancer Biology

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance

S. Xu, K. E. Ware, Y. Ding, S. Y. Kim, M. Sheth, S. Rao, W. Chan, A. J. Armstrong, W. C. Eward, M. K. Jolly, J. A. Somarelli

bioRxiv · Jul 10, 2018Cancer Biology

EMT and MET: necessary or permissive for metastasis?

M. K. Jolly, K. E. Ware, S. Gilja, J. A. Somarelli, H. Levine

This paper examines the role of EMT and MET in metastasis, arguing that these processes are not binary and proposes alternative mechanisms beyond the traditional EMT-MET model.

bioRxiv · Mar 29, 2017Cancer Biology