Author

M. Kanellias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:flow cytometry· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Velez· 2 shared L. Ewart· 2 shared S. J. Kerns· 2 shared S. Jadalannagari· 2 shared S. R. Joshipura· 2 shared W. Tien-Street· 2 shared A. Apostolou· 1 shared A. B. Roth· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

J. Velez

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications

P. L. Candarlioglu, S. Jadalannagari, J. Chaff, J. Velez, S. R. Joshipura, M. Kanellias, A. P. Simpson, S. J. Kerns, L. Ewart, M. Hegde, J. Ekert

This paper describes a Liver-Chip model that maintains CD32B expression on LSECs for 14 days, enabling in vitro studies of therapeutic antibody pharmacology.

bioRxiv · Mar 4, 2022 · PreprintBioengineering

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

L. Ewart, A. Apostolou, S. A. Briggs, C. V. Carman, J. T. Chaff, A. R. Heng, S. Jadalannagari, J. Janardhanan, K.-J. Jang, S. R. Joshipura, M. Kadam, M. Kanellias, V. J. Kujala, G. Kulkarni, C. Y. Le, , D. Levner

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

bioRxiv · Dec 14, 2021 · PreprintPharmacology & Toxicology

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

L. Cabon, D. Petropolis, W. Tien-Street, P. R. Ng, H. S. Grant, K. Karalis, G. A. Hamilton, J. Sam, T. Weinzierl, T. Fauti, A. Freimoser-Grundschober, J. Eckmann, C. Hage, M. Geiger, V. Micallef, , R. Barrile

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

bioRxiv · Feb 22, 2021Cancer Biology