L. Ewart

Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.

A Microengineered Brain-Chip to Model Neuroinflammation in Humans

The paper presents a human Brain-Chip that models neuroinflammation by recapitulating brain cell interactions and BBB function, showing improved complexity and clinical relevance compared to existing models.

Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications

This paper describes a Liver-Chip model that maintains CD32B expression on LSECs for 14 days, enabling in vitro studies of therapeutic antibody pharmacology.

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

Bone marrow-on-a-chip: Emulating the human bone marrow

This paper describes a bone marrow-on-a-chip model that supports long-term cultivation and differentiation of human hematopoietic stem and progenitor cells, demonstrating its utility for drug testing and transplantation studies.

Human bone marrow disorders recapitulated in vitro using organ chip technology

The paper describes a Bone Marrow-on-a-Chip model that mimics bone marrow function and disease states, including drug and radiation responses and Shwachman-Diamond Syndrome abnormalities.