A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma
A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess
The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.
bioRxiv · Nov 26, 2020 · PreprintCell Biology