Author

A. Burgess

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

A. Gonzalez-Rajal· 2 shared A. L. Bain· 2 shared D. N. Watkins· 2 shared D. R. Croucher· 2 shared D. Sinha· 2 shared J. F. Hastings· 2 shared K. k. Khanna· 2 shared M. Kalimutho· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Gonzalez-Rajal

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CTCF is essential for proper mitotic spindle structure and anaphase segregation

K. Chiu, Y. Berrada, N. Eskndir, D. Song, C. Fong, S. Naughton, T. Chen, S. Moy, S. Gyurmey, L. James, C. Ezeiruaku, C. Capistran, D. Lowey, V. Diwanji, S. Peterson, , A. D. Stephens

This study shows that CTCF is crucial for correct mitotic spindle structure and anaphase segregation, leading to abnormal nuclear morphology in interphase.

bioRxiv · Jan 9, 2023Cell Biology

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.

P. Gupta, S. E. Thomas, J. Cory-Wright, V. Sebastián-Pérez, A. Burgess, E. Cattermole, C. Meghir, C. Abell, A. G. Coyne, W. R. Jacobs, T. L. Blundell, S. Tiwari, V. Mendes

This study uses a fragment-based approach to assess the ligandability of four enzymes in the L-arginine biosynthesis pathway of M. tuberculosis, identifying potential drug targets.

bioRxiv · Mar 12, 2021Biochemistry

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

B. Rashidieh, B. Shohayeb, A. L. Bain, P. R. J. Fortuna, D. Sinha, A. Burgess, R. Mills, R. C. Adams, J. A. Lopez, P. Blumbergs, J. Finnie, M. Kalimutho, M. Piper, J. E. Hudson, D. Ng, K. k. Khanna

This study shows that Cep55 regulates PI3K/Akt signaling, essential for neocortical development and ciliogenesis, using mouse models and human organoids.

bioRxiv · Jan 8, 2021 · PreprintCell Biology

A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess

The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.

bioRxiv · Nov 26, 2020 · PreprintCell Biology

Cep55 overexpression promotes genomic instability and tumorigenesis in mice

D. Sinha, P. Nag, D. Nanayakkara, P. H. G. Duijf, A. Burgess, P. Raninga, V. A. J. Smits, A. L. Bain, G. N. Subramanian, M. Wall, J. W. Finnie, M. Kalimutho, K. K. Khanna

This study shows that Cep55 overexpression causes genomic instability and tumorigenesis in mice by promoting mitotic errors and disrupting DNA repair mechanisms.

bioRxiv · Sep 24, 2019Cancer Biology

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

J. F. Hastings, A. Gonzalez-Rajal, J. Z. Han, R. A. McCloy, Y. E. O'Donnell, M. Phimmachanh, A. D. Murphy, A. Nagrial, D. Daneshvar, V. Chin, D. N. Watkins, A. Burgess, D. R. Croucher

This study identifies P70S6K as a mediator of cisplatin resistance in lung adenocarcinoma using in vitro assays mimicking in vivo pharmacokinetics.

bioRxiv · Sep 20, 2019Cancer Biology