Author

R. A. McCloy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

V. Chin· 3 shared A. Burgess· 2 shared A. Gonzalez-Rajal· 2 shared D. N. Watkins· 2 shared D. R. Croucher· 2 shared J. F. Hastings· 2 shared A. D. Murphy· 1 shared A. Murphy· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

V. Chin

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Author profile →

3 papers

Recent·Most cited

Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx

V. Chin, W. Muskovic, R. A. McCloy, D. Neavin, J. Alquicira, H. Arora, A. Senabouth, P. Keith, E. Spenceley, A. Murphy, D. Kaczorowski, P. Floros, P. Earls, B. Leavers, J. Crawford, , J. Powell

This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.

bioRxiv · Apr 15, 2024 · PreprintCancer Biology

A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess

The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.

bioRxiv · Nov 26, 2020 · PreprintCell Biology

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

J. F. Hastings, A. Gonzalez-Rajal, J. Z. Han, R. A. McCloy, Y. E. O'Donnell, M. Phimmachanh, A. D. Murphy, A. Nagrial, D. Daneshvar, V. Chin, D. N. Watkins, A. Burgess, D. R. Croucher

This study identifies P70S6K as a mediator of cisplatin resistance in lung adenocarcinoma using in vitro assays mimicking in vivo pharmacokinetics.

bioRxiv · Sep 20, 2019Cancer Biology