Author

W. E. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Burgess· 1 shared A. Gonzalez-Rajal· 1 shared A. Harman· 1 shared A. J. Cesare· 1 shared D. N. Watkins· 1 shared D. R. Croucher· 1 shared D. R. Nguyen· 1 shared J. Cain· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCell Biology

A. Burgess

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Nuclear actin and DNA replication stress regulate the recruitment of human telomerase to telomeres

A. Harman, M. Kartawinata, N. M. Maroun, D. R. Nguyen, W. E. Hughes, K. Winardi, A. J. Cesare, N. Lamm, T. M. Bryan

The paper shows that nuclear actin and replication stress regulate telomerase recruitment to telomeres via ATR and mTOR, enabling telomere length maintenance in human cells.

bioRxiv · Mar 25, 2024Cancer Biology

A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess

The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.

bioRxiv · Nov 26, 2020 · PreprintCell Biology