M. Knopp

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

Hemi Manganese Exchangers 1 and 2 enable manganese import at the plasma membrane in cyanobacteria

This study identifies Hmx1 and Hmx2 as Mn importers in cyanobacteria, showing they enable Mn uptake at the plasma membrane and are ancestral to eukaryotic UPF0016 proteins.

High-throughput profiling of drug interactions in Gram-positive bacteria

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

Rescue of Escherichia coli auxotrophy by de novo small proteins

This study shows that de novo small proteins can rescue Escherichia coli auxotrophy by binding to RNA regulatory regions and increasing gene expression.

Loss of plastid developmental genes coincides with a reversion to monoplastidy in hornworts

The paper identifies the loss of ARC3 and FtsZ2 genes in hornworts as the cause of their monoplastidic phenotype through genomic and transcriptomic analysis.

The asgardarchaeal-unique contribution to protein families of the eukaryotic common ancestor was 0.3%

The paper analyzes the contribution of asgardarchaea to eukaryotic protein families and finds it accounts for only 0.3% of conserved eukaryotic protein families.