G. Zeller

Long-term fasting remodels gut microbial metabolism and host metabolism

This study shows that long-term fasting changes gut microbial composition and function, as well as the serum metabolome, with significant shifts in microbial species and metabolite levels.

Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants

This study reveals interindividual variability in gut microbial metabolism of immunosuppressive drugs mediated by specific bacterial species and enzymes.

Large-scale computational analyses of gut microbial CAZyme repertoires enabled by Cayman

The paper develops Cayman, a CAZyme profiler, to analyze gut microbial CAZyme repertoires and finds differences in substrate preferences between Western and non-Western metagenomes and CRC patients.

Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson's disease

This study uses machine learning to meta-analyze gut microbiome data from Parkinson's disease patients, identifying microbial pathways linked to disease and potential diagnostic applications.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

High-throughput profiling of drug interactions in Gram-positive bacteria

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

C. difficile may be overdiagnosed in adults and is a prevalent commensal in infants

This study finds that C. difficile is often overdiagnosed in adults and is a common commensal in infants, with distinct microbial associations across age groups.

Uncharted biosynthetic potential of the ocean microbiome

This study identifies over 40,000 putative biosynthetic gene clusters in ocean microbes, revealing novel biosynthetic potential and a new candidate genus with diverse metabolic capabilities.

Dissecting the collateral damage of antibiotics on gut microbes

This study characterizes the antibiotic activity spectrum on gut bacteria, revealing species-specific effects and identifying antidotes to mitigate collateral damage.

Extensive Transmission of Microbes along the Gastrointestinal Tract

The paper shows oral microbes commonly colonize the large intestine in healthy individuals and more so in disease states like colorectal cancer and rheumatoid arthritis.