Author

M. L. Jenior

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Bioengineering· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 6 Assay:bulk RNA-seq· 3 Assay:metabolomics· 3 Assay:metagenomics· 3 Organism:mouse· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

J. L. Leslie· 5 shared V. B. Young· 4 shared J. A. Papin· 3 shared P. D. Schloss· 3 shared K. C. Vendrov· 2 shared M. E. Dickenson· 2 shared A. Standke· 1 shared A. Wallqvist· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMicrobiology

J. L. Leslie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of Klebsiella pneumoniae

M. L. Jenior, M. E. Dickenson, J. A. Papin

The paper uses transcriptomic and metabolic modeling to show clinical isolates of Klebsiella pneumoniae rely more on valine catabolism, suggesting a potential immunosuppressive strategy.

npj Systems Biology and Applications · Oct 28, 2022Peer-reviewedMicrobiology

Identifying metabolic adaptations during cardiotoxicity using paired transcriptomics andmetabolomics data integrated with a model of heart metabolism

B. Dougherty, K. D. Rawls, M. L. Jenior, B. Chun, S. Nagdas, J. J. Saucerman, G. L. Kolling, A. Wallqvist, J. A. Papin

The paper integrates transcriptomics and metabolomics data with a heart metabolic model to identify metabolic adaptations during cardiotoxicity from three compounds.

bioRxiv · Oct 31, 2021 · PreprintBioengineering

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

J. L. Leslie, M. L. Jenior, K. C. Vendrov, A. Standke, M. R. Barron, T. J. O'Brien, L. Unverdorben, P. Thaprawat, I. L. Bergin, P. D. Schloss, V. B. Young

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

bioRxiv · Feb 26, 2021Microbiology

Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis

M. L. Jenior, J. L. Leslie, D. A. Powers, E. M. Garrett, K. A. Walker, M. E. Dickenson, W. A. Petri, R. Tamayo, J. A. Papin

This paper identifies novel metabolic drivers of virulence in C. difficile using genome-scale metabolic network analysis of two strains under different conditions.

bioRxiv · Nov 9, 2020Bioengineering

The gut microbiota is associated with clearance of Clostridium difficile infection independent of adaptive immunity

J. L. Leslie, K. C. Vendrov, M. L. Jenior, V. B. Young

This study shows that the gut microbiota, not adaptive immunity, is key for clearing C. difficile infection in mice, using Random Forest analysis to identify predictive bacterial members.

bioRxiv · Jan 6, 2019Microbiology

Clostridium difficile alters the structure and metabolism of distinct cecal microbiomes during initial infection to promote sustained colonization

M. L. Jenior, J. L. Leslie, V. B. Young, P. D. Schloss

This study shows that C. difficile infection alters gut microbiome structure and metabolism in mice pretreated with specific antibiotics, promoting persistent colonization.

bioRxiv · May 10, 2018Microbiology

Clostridium difficile colonizes alternative nutrient niches during infection across distinct murine gut microbiomes

M. L. Jenior, J. L. Leslie, V. B. Young, P. D. Schloss

This study shows C. difficile adapts its metabolism to different gut environments caused by antibiotic pretreatment, preferring nitrogen-containing carbon sources and host-derived glycans.

mSystems · Aug 29, 2017Peer-reviewedMicrobiology