Author

W. A. Petri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 7 Approach:experimental assay· 6 Organism:mouse· 6 Assay:bulk RNA-seq· 2 Assay:metagenomics· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. L. Leslie· 6 shared M. J. Uddin· 4 shared A. N. Donlan· 3 shared G. B. Moreau· 3 shared S. L. Burgess· 3 shared A. Frisbee· 2 shared B. Thompson· 2 shared J. A. Papin· 2 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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6 shared papersMicrobiology

J. L. Leslie

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Clostridioides difficile binary toxin binding component (CDTb) increases virulence in a hamster model

M. Simpson, T. Bilverstone, J. L. Leslie, A. Donlan, M. J. Uddin, W. Petri, N. Marin, C. Schwan, S. Kuehne, N. P. Minton, W. A. Petri

This study shows that CDTb, a component of C. difficile binary toxin, contributes to virulence by inducing inflammation and restoring virulence in a hamster model when expressed alone.

bioRxiv · Aug 3, 2021Microbiology

IL-13 promotes recovery from C. difficile infection

A. N. Donlan, J. L. Leslie, M. E. Simpson, W. A. Petri, J. E. Allen, W. A. Petri

This study shows IL-13 protects against C. difficile infection by promoting recovery and regulating macrophage polarization and monocyte dynamics.

bioRxiv · Aug 3, 2021 · PreprintImmunology

Fecal Microbiota Transplantation Drives Colonic Expression of Immune Activation Genes in a Mouse Model of Antibiotic Use

G. B. Moreau, H. Ozbek, P. Kumar, A. Frisbee, J. L. Leslie, W. A. Petri

This study shows that fecal microbiota transplantation (FMT) in a mouse model of antibiotic use increases microbial diversity and upregulates immune activation genes, particularly those associated with type 2 immunity.

bioRxiv · Jul 23, 2021 · PreprintMicrobiology

The IL-33-ILC2 pathway protects from amebic colitis

M. J. Uddin, J. L. Leslie, S. L. Burgess, N. Okland, B. Thompson, M. Abhyankar, A. Frisbee, A. N. Donlan, P. Kumar, W. A. Petri

This study shows that the IL-33-ILC2 pathway protects against amebic colitis by reducing inflammation and promoting tissue repair in mice.

bioRxiv · Jun 14, 2021Immunology

Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis

M. L. Jenior, J. L. Leslie, D. A. Powers, E. M. Garrett, K. A. Walker, M. E. Dickenson, W. A. Petri, R. Tamayo, J. A. Papin

This paper identifies novel metabolic drivers of virulence in C. difficile using genome-scale metabolic network analysis of two strains under different conditions.

bioRxiv · Nov 9, 2020Bioengineering

Megasphaera in the stool microbiota is negatively associated with diarrheal cryptosporidiosis

M. A. Carey, G. L. Medlock, M. Alam, M. Kabir, M. J. Uddin, U. Nayak, J. A. Papin, A. S. G. Faruque, R. Haque, W. A. Petri, C. A. Gilchrist

The paper finds that lower Megasphaera abundance in stool microbiota is associated with diarrheal symptoms in infants infected with Cryptosporidium.

bioRxiv · Oct 1, 2020Microbiology

Evaluation of K18-hACE2 mice as a model of SARS-CoV-2 infection

G. B. Moreau, S. L. Burgess, J. M. Sturek, A. N. Donlan, W. A. Petri, B. J. Mann

This study evaluates K18-hACE2 mice as a model for SARS-CoV-2 infection, showing they develop weight loss and lung pathology but limited clinical symptoms.

bioRxiv · Jun 26, 2020Pathology

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis

S. L. Burgess, J. L. Leslie, M. J. Uddin, N. Oakland, K. Watanabe, C. Gilchrist, G. B. Moreau, M. Saleh, M. Simpson, B. Thompson, D. T. Auble, S. Turner, N. Giallourou, J. Swann, Z. Pu, , W. A. Petri

The paper shows that introducing Clostridium scindens into the gut microbiota epigenetically alters bone marrow and provides protection against Entamoeba histolytica infection.

bioRxiv · Aug 7, 2019Microbiology