Author

J. L. Leslie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 8 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 9 Research Focus:host-pathogen & immune response· 8 Approach:experimental assay· 7 Assay:metagenomics· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

W. A. Petri· 6 shared M. L. Jenior· 5 shared V. B. Young· 5 shared P. D. Schloss· 4 shared M. J. Uddin· 3 shared A. Frisbee· 2 shared A. N. Donlan· 2 shared B. Thompson· 2 shared

Activity by Year

2017-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

W. A. Petri

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

The gut bacterial community potentiates Clostridioides difficile infection severity

N. A. Lesniak, A. M. Schubert, K. J. Flynn, J. L. Leslie, H. Sinani, I. L. Bergin, V. B. Young, P. D. Schloss

This study shows that gut bacterial communities influence the severity of Clostridioides difficile infections in mice, with certain bacterial groups linked to more or less severe outcomes.

bioRxiv · Jan 31, 2022Microbiology

Clostridioides difficile binary toxin binding component (CDTb) increases virulence in a hamster model

M. Simpson, T. Bilverstone, J. L. Leslie, A. Donlan, M. J. Uddin, W. Petri, N. Marin, C. Schwan, S. Kuehne, N. P. Minton, W. A. Petri

This study shows that CDTb, a component of C. difficile binary toxin, contributes to virulence by inducing inflammation and restoring virulence in a hamster model when expressed alone.

bioRxiv · Aug 3, 2021Microbiology

IL-13 promotes recovery from C. difficile infection

A. N. Donlan, J. L. Leslie, M. E. Simpson, W. A. Petri, J. E. Allen, W. A. Petri

This study shows IL-13 protects against C. difficile infection by promoting recovery and regulating macrophage polarization and monocyte dynamics.

bioRxiv · Aug 3, 2021 · PreprintImmunology

Fecal Microbiota Transplantation Drives Colonic Expression of Immune Activation Genes in a Mouse Model of Antibiotic Use

G. B. Moreau, H. Ozbek, P. Kumar, A. Frisbee, J. L. Leslie, W. A. Petri

This study shows that fecal microbiota transplantation (FMT) in a mouse model of antibiotic use increases microbial diversity and upregulates immune activation genes, particularly those associated with type 2 immunity.

bioRxiv · Jul 23, 2021 · PreprintMicrobiology

The IL-33-ILC2 pathway protects from amebic colitis

M. J. Uddin, J. L. Leslie, S. L. Burgess, N. Okland, B. Thompson, M. Abhyankar, A. Frisbee, A. N. Donlan, P. Kumar, W. A. Petri

This study shows that the IL-33-ILC2 pathway protects against amebic colitis by reducing inflammation and promoting tissue repair in mice.

bioRxiv · Jun 14, 2021Immunology

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

J. L. Leslie, M. L. Jenior, K. C. Vendrov, A. Standke, M. R. Barron, T. J. O'Brien, L. Unverdorben, P. Thaprawat, I. L. Bergin, P. D. Schloss, V. B. Young

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

bioRxiv · Feb 26, 2021Microbiology

Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis

M. L. Jenior, J. L. Leslie, D. A. Powers, E. M. Garrett, K. A. Walker, M. E. Dickenson, W. A. Petri, R. Tamayo, J. A. Papin

This paper identifies novel metabolic drivers of virulence in C. difficile using genome-scale metabolic network analysis of two strains under different conditions.

bioRxiv · Nov 9, 2020Bioengineering

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis

S. L. Burgess, J. L. Leslie, M. J. Uddin, N. Oakland, K. Watanabe, C. Gilchrist, G. B. Moreau, M. Saleh, M. Simpson, B. Thompson, D. T. Auble, S. Turner, N. Giallourou, J. Swann, Z. Pu, , W. A. Petri

The paper shows that introducing Clostridium scindens into the gut microbiota epigenetically alters bone marrow and provides protection against Entamoeba histolytica infection.

bioRxiv · Aug 7, 2019Microbiology

The gut microbiota is associated with clearance of Clostridium difficile infection independent of adaptive immunity

J. L. Leslie, K. C. Vendrov, M. L. Jenior, V. B. Young

This study shows that the gut microbiota, not adaptive immunity, is key for clearing C. difficile infection in mice, using Random Forest analysis to identify predictive bacterial members.

bioRxiv · Jan 6, 2019Microbiology

Clostridium difficile alters the structure and metabolism of distinct cecal microbiomes during initial infection to promote sustained colonization

M. L. Jenior, J. L. Leslie, V. B. Young, P. D. Schloss

This study shows that C. difficile infection alters gut microbiome structure and metabolism in mice pretreated with specific antibiotics, promoting persistent colonization.

bioRxiv · May 10, 2018Microbiology

Clostridium difficile colonizes alternative nutrient niches during infection across distinct murine gut microbiomes

M. L. Jenior, J. L. Leslie, V. B. Young, P. D. Schloss

This study shows C. difficile adapts its metabolism to different gut environments caused by antibiotic pretreatment, preferring nitrogen-containing carbon sources and host-derived glycans.

bioRxiv · Jun 29, 2017Microbiology