R. Tamayo

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy

This study identifies distinct growth and chaining properties in Clade 5 Clostridioides difficile strains using time-lapse microscopy, linked to the cmr switch sequence orientation.

Clostridioides difficile-mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation

This study investigates how C. difficile uses host-derived mucus for growth, metabolism, and biofilm formation, revealing metabolic shifts and potential pathogenic mechanisms.

c-di-GMP inhibits early sporulation in Clostridioides difficile

This study shows that c-di-GMP inhibits early sporulation in C. difficile by reducing sporulation frequency and gene transcription, suggesting a regulatory role in spore formation.

Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile

This study shows that phase variation of the PdcB phosphodiesterase in C. difficile modulates intracellular c-di-GMP levels, affecting multiple phenotypes to enhance survival.

Multiple regulatory mechanisms control the production of CmrRST, an atypical signal transduction system in Clostridioides difficile

This study identifies multiple regulatory mechanisms controlling cmrRST expression in C. difficile, including phase variation, c-di-GMP signaling, and autoregulation by CmrR.

Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides difficile infection

This study shows that flagellum and toxin phase variation in C. difficile affects intestinal colonization and disease development in mouse models.

Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis

This paper identifies novel metabolic drivers of virulence in C. difficile using genome-scale metabolic network analysis of two strains under different conditions.

Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence

This paper identifies a phase-variable signal transduction system in C. difficile that controls colony morphology, motility, and virulence, with implications for bacterial survival and pathogenesis.

Characterization of flagellar and toxin phase variation in Clostridium difficile ribotype 012 isolates

The paper examines flagellar and toxin phase variation in C. difficile ribotype 012 isolates, finding heterogeneity in their ability to switch between motile/toxigenic and non-motile/nontoxigenic states.