Author

M. L. Schotzko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pathology· 2 Physiology· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Organism:rat· 4 Organism:non-human primate· 3 Research Focus:development & morphogenesis· 2 Assay:imaging· 2 Assay:behavioral assay· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

H. A. Simmons· 5 shared A. M. Weiler· 4 shared C. M. Newman· 4 shared D. H. O'Connor· 4 shared D. M. Dudley· 4 shared E. L. Mohr· 4 shared J. M. Hayes· 4 shared L. M. Stewart· 4 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersPhysiology

H. A. Simmons

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

J. Schmidt, R. Wilson, B. Davenport, T. Hacker, C. Fitz, H. A. Simmons, M. L. Schotzko, T. Golos, H. Jones

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.

bioRxiv · Apr 10, 2024Physiology

Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates

R. L. Wilson, J. Kropp Schmidt, B. N. Davenport, E. Ren, L. T. Keding, S. Shaw, M. L. Schotzko, K. Antony, H. A. Simmons, T. Golos, H. Jones

This study evaluates maternal, placental, and fetal responses to non-viral nanoparticle-mediated IGF1 gene therapy in nonhuman primates, finding no adverse effects and placental signaling changes indicating homeostasis maintenance.

bioRxiv · Jun 16, 2023 · PreprintPhysiology

Quantification of Early Gait Development: Expanding the Application of Catwalk Technology to an Infant Rhesus Macaque Model

S. A. Kabakov, E. Crary, V. Menna, E. R. Razo, J. C. Eickhoff, N. R. Dulaney, J. R. Drew, K. Bach, A. M. Poole, M. Stumpf, A. M. Mitzey, K. B. Malicki, M. L. Schotzko, K. A. Pickett, N. J. Schultz-Darken, , K. K. Ausderau

This paper assesses gait development in infant rhesus macaques using the Noldus Catwalk system, finding that diagonal walking patterns emerge early and gait parameters show limited change over the first month.

bioRxiv · Nov 14, 2022Animal Behavior & Cognition

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

M. R. Koenig, E. Razo, A. Mitzey, C. M. Newman, D. M. Dudley, M. E. Breitbach, M. R. Semler, L. M. Stewart, A. M. Weiler, S. Rybarczyk, K. M. Bach, M. M. Mohns, H. A. Simmons, A. Mejia, M. Fritsch, , O'Connor

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

bioRxiv · Jul 18, 2020 · PreprintMicrobiology

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

M. T. Aliota, D. M. Dudley, C. M. Newman, J. Weger-Lucarelli, L. M. Stewart, M. R. Koenig, M. E. Breitbach, A. M. Weiler, M. R. Semler, G. L. Barry, K. R. Zarbock, M. S. Mohns, E. L. Mohr, V. Venturi, N. Schultz-Darken, , D. H. O'Connor

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

bioRxiv · Nov 17, 2017Microbiology

Ocular and uteroplacental pathology in macaque congenital Zika virus infection

E. L. Mohr, L. N. Block, C. M. Newman, L. M. Stewart, M. Koenig, M. Semler, M. E. Breitbach, L. B. C. Teixeira, X. Zeng, A. M. Weiler, G. L. Barry, T. H. Thoong, G. J. Wiepz, D. M. Dudley, H. A. Simmons, , T. G. Golos

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

bioRxiv · Sep 30, 2017Pathology

Highly Efficient Maternal-Fetal Zika Virus Transmission in Pregnant Rhesus Macaques

S. M. Nguyen, K. M. Antony, D. M. Dudley, S. Kohn, H. Simmons, B. Wolfe, M. S. Salamat, L. B. Teixeira, G. J. Wiepz, T. H. Thoong, M. T. Aliota, A. M. Weiler, G. L. Barry, K. L. Weisgrau, L. J. Vosler, , T. G. Golos

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

bioRxiv · May 11, 2017Pathology