Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation
E. Bracho-Sanchez, F. Rocha, S. K. Bedingfield, B. D. Partain, M. A. Brusko, J. M. Colazo, M. M. Fettis, S. A. Farhadi, E. Y. Helm, K. Koenders, A. J. Kwiatkowski, S. L. Macias, A. Restuccia, A. Wanchoo, D. Avram, , B. G. Keselowsky
This paper develops a fusion protein IDO-Gal3 that anchors immunosuppressive enzymes to tissues, effectively suppressing local inflammation in multiple disease models.
bioRxiv · May 7, 2021 · PreprintBioengineering