Author

M. A. Brusko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

A. L. Posgai· 2 shared C. H. Wasserfall· 2 shared M. A. Atkinson· 2 shared A. J. Kwiatkowski· 1 shared A. K. Mojica-Avila· 1 shared A. Muir· 1 shared A. Restuccia· 1 shared A. Wanchoo· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPathology

A. L. Posgai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

D. Drotar, A. K. Mojica-Avila, D. T. Bloss, C. M. Cohrs, C. T. Manson, A. L. Posgai, M. D. Williams, M. A. Brusko, E. A. Phelps, C. H. Wasserfall, S. Speier, M. A. Atkinson

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

bioRxiv · Feb 8, 2024 · PreprintPathology

Human immune phenotyping reveals accelerated aging in type 1 diabetes

M. R. Shapiro, X. Dong, D. Perry, J. M. McNichols, P. Thirawatananond, A. L. Posgai, L. Peters, K. Motwani, R. Musca, A. Muir, P. Concannon, L. Jacobsen, C. E. Mathews, C. H. Wasserfall, M. J. Haller, , T. M. Brusko

The paper uses flow cytometry to show accelerated immune aging and age-adjusted proinflammatory phenotypes in type 1 diabetes.

JCI Insight · Sep 8, 2023Peer-reviewedImmunology

Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation

E. Bracho-Sanchez, F. Rocha, S. K. Bedingfield, B. D. Partain, M. A. Brusko, J. M. Colazo, M. M. Fettis, S. A. Farhadi, E. Y. Helm, K. Koenders, A. J. Kwiatkowski, S. L. Macias, A. Restuccia, A. Wanchoo, D. Avram, , B. G. Keselowsky

This paper develops a fusion protein IDO-Gal3 that anchors immunosuppressive enzymes to tissues, effectively suppressing local inflammation in multiple disease models.

bioRxiv · May 7, 2021 · PreprintBioengineering