Endogenous CD28 drives CAR T cell responses in multiple myeloma
M. M. Lieberman, J. H. Tong, N. U. Odukwe, C. A. Chavel, T. J. Purdon, R. Burchett, B. M. Gillard, C. M. Brackett, A. R. McGray, J. L. Bramson, R. J. Brentjens, K. P. Lee, S. H. Olejniczak
This study shows that endogenous CD28 signaling is essential for CAR T cell efficacy in multiple myeloma, and transient CD28 blockade may reduce toxicities without compromising long-term survival.
bioRxiv · Mar 21, 2024 · PreprintCancer Biology