K. P. Lee

Endogenous CD28 drives CAR T cell responses in multiple myeloma

This study shows that endogenous CD28 signaling is essential for CAR T cell efficacy in multiple myeloma, and transient CD28 blockade may reduce toxicities without compromising long-term survival.

Plastid-specific RsmD methyltransferase and ribosome maturation factor RimM are crucial for 16S rRNA maturation and proteostasis

This study identifies chloroplast-specific factors AtRsmD and AtRimM essential for 16S rRNA maturation and chloroplast proteostasis in Arabidopsis thaliana.

ARS2-directed alternative splicing mediates CD28 driven T cell glycolysis and effector function

This study shows ARS2 promotes CD28-driven T cell glycolysis and effector function through alternative splicing of Pkm2, enhancing anti-tumor immunity.

Antagonistic modules, SIB1 and LSD1, regulate photosynthesis-associated nuclear genes via GOLDEN2-LIKE transcription factors in Arabidopsis

This study shows SIB1 and LSD1 antagonistically regulate GLK1/2 to control PhANGs expression, affecting chloroplast biogenesis and 1O2 homeostasis in Arabidopsis.

A hierarchy of migratory keratinocytes maintains the tympanic membrane

This study identifies a three-dimensional differentiation hierarchy of keratinocytes in the tympanic membrane using single-cell RNA sequencing and live-cell imaging.

PLANT NATRIURETIC PEPTIDE A antagonizes salicylic acid-primed cell death

The paper shows that PNP-A antagonizes SA-mediated cell death in Arabidopsis lsd1 mutants by interacting with a newly identified receptor PNPAR.