Author

M. M. Schaefers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

G. P. Priebe· 4 shared C. Merakou· 2 shared K. E. Mansour· 2 shared A. DiGiandomenico· 1 shared A. J. McAdam· 1 shared A. J. Poret· 1 shared A. R. Cross· 1 shared A. Z. Uluer· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

G. P. Priebe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

A. J. Poret, M. M. Schaefers, C. Merakou, K. E. Mansour, G. K. Lagoudas, A. R. Cross, J. B. Goldberg, R. Kishony, A. Z. Uluer, A. J. McAdam, P. C. Blainey, S. O. Vargas, T. D. Lieberman, G. P. Priebe

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

bioRxiv · Feb 6, 2024 · PreprintMicrobiology

Small-molecule activators of a bacterial signaling pathway inhibit virulence

K. E. Mansour, Y. Qi, M. Yan, O. Ramstrom, G. P. Priebe, M. M. Schaefers

This study identifies small-molecule activators of the FixLJ pathway in Burkholderia that inhibit virulence without toxicity.

bioRxiv · Dec 2, 2023 · PreprintMicrobiology

Multicomponent Pseudomonas aeruginosa vaccines eliciting Th17 cells and functional antibody responses confer enhanced protection against experimental acute pneumonia in mice

M. O. F. Shaikh, M. M. Schaefers, C. Merakou, M. DiBlasi, S. Bonney, T. Liao, D. Zurakowski, M. Kehl, D. E. Tabor, A. DiGiandomenico, G. P. Priebe

This study evaluates a multicomponent Pseudomonas aeruginosa vaccine combining PopB/PcrH and OprF/I, showing enhanced protection against pneumonia in mice through Th17 responses and functional antibodies.

bioRxiv · May 5, 2022Immunology

Host adaptations in the fixLJ pathway of the Burkholderia cepacia complex increase virulence

M. M. Schaefers, B. X. Wang, N. M. Boisvert, S. J. Martini, S. L. Bonney, C. W. Marshall, M. T. Laub, V. S. Cooper, G. P. Priebe

This study shows that evolved variants of the fixLJ pathway in BCC species enhance virulence in host models but reduce survival in soil.

bioRxiv · May 4, 2020 · PreprintMicrobiology