Author

M. M. Welch

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Yildiz· 1 shared B. P. Kleinstiver· 1 shared J. A. Doudna· 1 shared J. K. Joung· 1 shared J. S. Chen· 1 shared L. B. Harrington· 1 shared S. H. Sternberg· 1 shared Y. S. Dagdas· 1 shared

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2017-2017 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

A. Yildiz

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1 paper

Recent·Most cited

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

J. S. Chen, Y. S. Dagdas, B. P. Kleinstiver, M. M. Welch, L. B. Harrington, S. H. Sternberg, J. K. Joung, A. Yildiz, J. A. Doudna

This study identifies a mechanism by which CRISPR-Cas9 variants discriminate target mismatches and introduces a hyper-accurate variant with improved specificity.

bioRxiv · Aug 12, 2017Biochemistry