Author

Y. S. Dagdas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Yildiz· 2 shared J. A. Doudna· 2 shared J. S. Chen· 2 shared S. H. Sternberg· 2 shared B. P. Kleinstiver· 1 shared J. K. Joung· 1 shared L. B. Harrington· 1 shared M. M. Welch· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

A. Yildiz

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2 papers

Recent·Most cited

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

J. S. Chen, Y. S. Dagdas, B. P. Kleinstiver, M. M. Welch, L. B. Harrington, S. H. Sternberg, J. K. Joung, A. Yildiz, J. A. Doudna

This study identifies a mechanism by which CRISPR-Cas9 variants discriminate target mismatches and introduces a hyper-accurate variant with improved specificity.

bioRxiv · Aug 12, 2017Biochemistry

A Conformational Checkpoint Between DNA Binding And Cleavage By CRISPR-Cas9

Y. S. Dagdas, J. S. Chen, S. H. Sternberg, J. A. Doudna, A. Yildiz

This study identifies a conformational checkpoint in CRISPR-Cas9 that regulates DNA cleavage by requiring divalent cations and preventing cleavage at off-target sites with sequence mismatches.

bioRxiv · Mar 30, 2017Biophysics