Author

L. B. Harrington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

J. A. Doudna· 2 shared J. S. Chen· 2 shared A. Yildiz· 1 shared B. P. Kleinstiver· 1 shared E. Ma· 1 shared J. K. Joung· 1 shared M. M. Welch· 1 shared S. H. Sternberg· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

J. A. Doudna

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Author profile →

2 papers

Recent·Most cited

CRISPR-Cas12a target binding unleashes single-stranded DNase activity

J. S. Chen, E. Ma, L. B. Harrington, X. Tian, J. A. Doudna

This study shows that CRISPR-Cas12a activates non-specific single-stranded DNA cleavage upon guide RNA-dependent DNA binding, distinguishing it from CRISPR-Cas9.

bioRxiv · Nov 29, 2017Biochemistry

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

J. S. Chen, Y. S. Dagdas, B. P. Kleinstiver, M. M. Welch, L. B. Harrington, S. H. Sternberg, J. K. Joung, A. Yildiz, J. A. Doudna

This study identifies a mechanism by which CRISPR-Cas9 variants discriminate target mismatches and introduces a hyper-accurate variant with improved specificity.

bioRxiv · Aug 12, 2017Biochemistry