Author

M. Madej

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Potempa· 3 shared C. Scavenius· 2 shared Z. Nowakowska· 2 shared A. Basle· 1 shared A. Jacula· 1 shared A. M. Lasica· 1 shared A. Saran· 1 shared B. van den Berg· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

J. Potempa

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Author profile →

3 papers

Recent·Most cited

Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights

A. Saran, H.-M. Kim, I. Manning, M. A. Hancock, C. Schmitz, M. Madej, J. Potempa, M. Sola, J.-F. Trempe, Y. Zhu, M. Davey, N. Zeytuni

This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.

bioRxiv · May 15, 2024Biochemistry

The essential Porphyromonas gingivalis type IX secretion system component PorZ delivers anionic-lipopolysaccharide to the PorU sortase for transpeptidase processing of cargos

M. Madej, Z. Nowakowska, M. Ksiazek, A. M. Lasica, D. Mizgalska, N. Magdalena, A. Jacula, C. Scavenius, J. J. Enghild, J. Aduse-Opoku, M. A. Curtis, F. X. Gomis-Rüth, J. Potempa

This paper identifies PorZ as a T9SS component that binds anionic lipopolysaccharide (A-LPS) and interacts with the PorU sortase to facilitate cargo protein anchoring to the outer membrane.

mBio · Feb 23, 2021Peer-reviewedMicrobiology

Dynamic oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis

M. Madej, J. White, Z. Nowakowska, S. Rawson, C. Scavenius, J. Enghild, G. Bereta, K. Pothula, U. Kleinekathoefer, A. Basle, N. Ranson, J. Potempa, B. van den Berg

This study identifies RagAB as the oligopeptide transporter in P. gingivalis, revealing its structure and mechanism for nutrient uptake from the extracellular environment.

bioRxiv · Sep 4, 2019Microbiology