M. Davey

Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights

This study characterizes PorX, a response regulator in the Type-IX secretion system, revealing its unique enzymatic activity and zinc-dependent dimerization, with implications for virulence factor secretion in bacterial pathogens.

An acylated N-terminus and a conserved loop regulate the activity of the ABHD17 de-acylase

This study identifies two regulatory elements in ABHD17 enzymes that modulate their activity through S-acylation and membrane interactions.

Inhibition of SARS-CoV-2 infection by Porphyromonas gingivalis and the oral microbiome

This study shows that Porphyromonas gingivalis and other oral bacteria can inhibit SARS-CoV-2 infection through cytotoxicity and unknown mechanisms, with individual variation in oral microbiome activity.

N-terminal signals in the SNX-BAR paralogs Vps5 and Vin1 guide coat complex formation

This study identifies N-terminal signals in Vin1 and Vps5 that guide the formation of specific endosomal coat complexes in yeast.

Elevation-dependent patterns of snow-gum dieback are moderated by trait differences between montane and subalpine forests.

The paper examines elevation-dependent patterns of snow-gum dieback and finds trait differences between montane and subalpine subspecies influence borer-damage severity.

Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae

The paper screens yeast mutants to identify genes that enhance recombinant laccase secretion, finding that vesicle trafficking and chaperone proteins are critical for improved protein production.

Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat

This study identifies and functionally validates the WAPO1 gene's role in increasing spikelets per spike in wheat, showing its positive correlation with yield potential.

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

The VINE complex is a VPS9-domain GEF-containing SNX-BAR coat involved in endosomal sorting

The paper identifies the VINE complex, a SNX-BAR coat containing Vrl1 and Vin1, which regulates endosomal sorting and signaling.

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

The paper systematically analyzes membrane contact sites in yeast to identify new proteins involved in lipid distribution.

The status of current and tentative marine natural World Heritage areas

The paper assesses human impacts and representation in marine natural World Heritage areas, finding high impacts in tentative sites and gaps in ecoregion and species coverage.