Author

M. Mandelboim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 7 Approach:experimental assay· 5 Organism:human· 5 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Mendelson· 3 shared I. Nemet· 2 shared J. Jacob-Hirsch· 2 shared L. Kliker· 2 shared M. Aftalion· 2 shared N. Friedman· 2 shared N. Paran· 2 shared T. Chitlaru· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. Mendelson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Dual neutralization of influenza virus hemagglutinin and neuraminidase by a bispecific antibody leads to improved antiviral activity

R. Moirangthem, S. Cordela, D. Khateeb, M. Mandelboim, F. Jonsson, T. Bruel, Y. Bar-On

This study shows a bispecific antibody targeting both influenza virus hemagglutinin and neuraminidase improves antiviral activity by blocking infection and preventing virus release.

bioRxiv · Mar 16, 2023Immunology

P681 mutations within the polybasic motif of spike dictate fusogenicity and syncytia formation of SARS CoV-2 variants

A. Kuzmina, N. Atari, A. Ottolenghi, D. Korovin, I. Cohen Lass, B. Rosental, E. Rosenberg, M. Mandelboim, R. Taube

This study investigates how mutations at position 681 of the SARS-CoV-2 spike protein affect viral fusogenicity and syncytia formation across variants.

bioRxiv · Apr 26, 2022 · PreprintMicrobiology

SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern

O. Alfi, M. Hamdan, O. Wald, A. Yakirevitch, O. Wandel, E. Oiknine-Djian, B. Gvili, H. Knoller, N. Rozendorn, H. Golan Berman, S. Adar, O. Vorontsov, M. Mandelboim, Z. Zakay-Rones, M. Oberbaum, , D. Wolf

This study compares SARS-CoV-2 Omicron replication in human lung and nasal tissues to other variants, finding restricted replication in lungs and a stronger interferon response.

bioRxiv · Mar 31, 2022 · PreprintMicrobiology

CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2.

M. Israeli, Y. Finkel, Y. Yahalom-Rone, N. Paran, T. Chitlaru, O. Israeli, I. Cohen-Gihon, M. Aftalion, R. Falach, U. Elia, I. Nemet, L. Kliker, M. Mandelboim, A. Beth-Din, T. Israely, , A. Bercovich-Kinori

This study uses CRISPR screens to identify host factors critical for SARS-CoV-2 infection, finding GATA6 as a key modulator of ACE2 expression and viral entry.

bioRxiv · Jul 19, 2021 · PreprintMicrobiology

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against novel viral variants

E. Makdasi, A. Zvi, R. Alcalay, T. Noy-Porat, E. Peretz, A. Mechaly, Y. Levy, E. Epstein, T. Chitlaru, A. Tennenhouse, M. Aftalion, D. Gur, N. Paran, H. Tamir, O. Zimhony, , R. Rosenfeld

This study evaluates the neutralization potency of four SARS-CoV-2 mAbs against spike mutations and two variants of concern, finding that MD65 and BL6 retain effectiveness against B.1.1.7 and B.1.351.

bioRxiv · Apr 1, 2021Immunology

Transcriptomic profiling of human corona virus (HCoV)-229E -infected human cells and genomic mutational analysis of HCoV-229E and SARS-CoV-2

N. Friedman, J. Jacob-Hirsch, Y. Drori, E. Eyal, N. Kol, O. Nayshool, E. Mendelson, G. Rechavi, M. Mandelboim

This study uses transcriptomic analysis to identify cellular pathway changes in HCoV-229E-infected cells and links APOBEC3B activity to genomic mutations in SARS-CoV-2.

bioRxiv · Aug 17, 2020Microbiology

Influenza virus inhibits respiratory syncytial virus (RSV) infection via a two-wave expression of interferon-induced protein with tetratricopeptide (IFIT) proteins

Y. Drori, J. Jacob-Hirsch, R. Pando, A. Glatman-Freedman, N. Friedman, E. Mendelson, M. Mandelboim

This study shows influenza virus inhibits RSV infection through a two-wave upregulation of IFIT proteins, observed in both in vitro and in vivo models.

bioRxiv · Aug 17, 2020Microbiology