Author

O. Israeli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Beth-Din· 4 shared D. Stein· 4 shared N. Paran· 4 shared H. Achdout· 3 shared I. Cohen-Gihon· 3 shared S. Lazar· 3 shared S. Melamed· 3 shared S. Weiss· 3 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

A. Beth-Din

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2.

M. Israeli, Y. Finkel, Y. Yahalom-Rone, N. Paran, T. Chitlaru, O. Israeli, I. Cohen-Gihon, M. Aftalion, R. Falach, U. Elia, I. Nemet, L. Kliker, M. Mandelboim, A. Beth-Din, T. Israely, , A. Bercovich-Kinori

This study uses CRISPR screens to identify host factors critical for SARS-CoV-2 infection, finding GATA6 as a key modulator of ACE2 expression and viral entry.

bioRxiv · Jul 19, 2021 · PreprintMicrobiology

Mice with Induced Pulmonary Comorbidities Display Severe Lung Inflammation and Mortality following Exposure to SARS-CoV-2

R. Falach, L. Bar-On, S. Lazar, T. Kadar, O. Mazor, M. Aftalion, D. Gur, O. Shifman, O. Israeli, I. Cohen-Gihon, G. Zaide, H. Gutman, Y. Evgy, Y. Vagima, E. Makdasi, , T. Sabo

This study shows that CD-1 mice with induced pulmonary comorbidities develop severe lung inflammation and high mortality after SARS-CoV-2 infection.

bioRxiv · Oct 28, 2020 · PreprintPathology

The coding capacity of SARS-CoV-2

Y. Finkel, O. Mizrahi, A. Nachshon, S. Weingarten-Gabbay, D. Morgenstern, Y. Yahalom-Ronen, H. Tamir, H. Achdout, D. Stein, O. Israeli, A. Beth-Din, S. Melamed, S. Weiss, T. Isrealy, N. Paran, , N. Stern-Ginossar

This study maps the full coding capacity of SARS-CoV-2 using ribosome profiling, identifying 23 novel translated ORFs and revealing viral translation dominance over host translation.

Nature · Sep 9, 2020Peer-reviewedMicrobiology

A single dose of recombinant VSV-{triangleup}G-spike vaccine provides protection against SARS-CoV-2 challenge

Y. Yahalom-Ronen, H. Tamir, S. Melamed, B. Politi, O. Shifman, H. Achdout, E. B. Vitner, O. Israeli, E. Milrot, D. Stein, I. Cohen-Gihon, S. Lazar, H. Gutman, I. Glinert, L. Cherry, , T. Israely

This study develops a recombinant VSV-ΔG-spike vaccine that provides single-dose protection against SARS-CoV-2 in hamsters by inducing neutralizing antibodies and preventing lung pathology.

bioRxiv · Jun 18, 2020Microbiology

Evaluating the efficacy of RT-qPCR SARS-CoV-2 direct approaches in comparison to RNA extraction

O. Israeli, A. Beth-Din, N. Paran, D. Stein, S. Lazar, S. Weiss, E. Milrot, Y. Atiya-Nasagi, S. Yitzhaki, O. Laskar, O. Schuster

The paper compares RT-qPCR efficacy with and without RNA extraction for SARS-CoV-2 detection, finding that extraction is advantageous but a direct no-buffer approach can identify up to 70% of clinical specimens.

bioRxiv · Jun 10, 2020Microbiology