D. Wolf

NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms

This study shows that NLRP3 inflammasome activation drives JAK2V617F mutant myeloproliferative neoplasms by promoting inflammation, platelet production, and fibrosis, and that its inhibition can reverse disease features.

The CCR4/CCL17 axis drives intestinal acute Graft versus Host disease after allogeneic bone marrow transplantation

This study shows that the CCR4/CCL17 axis promotes intestinal acute GvHD by recruiting T cells and increasing Gata3 expression, and identifies ruxolitinib as a potential therapeutic.

Non-preferential, but detrimental accumulation of macrophages with clonal hematopoiesis-driver mutations in cardiovascular tissues

The paper quantifies CHIP mutated macrophages in cardiovascular tissues and finds they do not preferentially accumulate but exhibit a more disease-prone phenotype.

Comparative Analysis of Whole Transcriptome Single-Cell Sequencing Technologies in Complex Tissues

This study compares two scRNA-seq platforms, finding differences in cell population abundance and mRNA quantification, guiding platform selection and data interpretation.

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

This study provides a comprehensive transcriptomic analysis of the cell wall stress response in Bacillus subtilis, identifying key regulatory factors and developing biosensors for envelope stress detection.

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

This study shows that the BNT162b2 mRNA vaccine induces temporary salivary IgA with strong neutralizing activity against SARS-CoV-2.

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

The paper integrates single-cell data to create a high-resolution atlas of NSCLC tumor microenvironments, revealing immune cell diversity, neutrophil plasticity, and associations with treatment outcomes.

SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern

This study compares SARS-CoV-2 Omicron replication in human lung and nasal tissues to other variants, finding restricted replication in lungs and a stronger interferon response.

SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection

This paper develops RBD-Ig fusion proteins that efficiently neutralize SARS-CoV-2 infection in vitro and in vivo, outperforming ACE2-Ig.

Phyletic distribution and diversification of the Phage Shock Protein stress response system in bacteria and archaea

This study investigates the phyletic distribution and diversification of the Phage Shock Protein (PSP) stress response system across bacteria and archaea using comparative genomics and protein interaction analysis.

The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing

This paper identifies UL147A as an HCMV protein that specifically downregulates MICA*008 to evade NK cell-mediated killing.

High-Throughput Image Analysis of Lipid-Droplet-Bound Mitochondria

The paper introduces a machine learning method to segment mitochondria in BAT images, revealing differences in H2O2 production between cytosolic and peri-droplet mitochondria.

Germline genetic contribution to the immune landscape of cancer

This study identifies germline genetic variants associated with immune traits in cancer, revealing their impact on the tumor immune microenvironment.

Human Cytomegalovirus Genomes Sequenced Directly from Clinical Material: Variation, Multiple-Strain Infection, Recombination and Mutation

The paper sequences HCMV genomes from clinical samples to study variation, multiple-strain infection, recombination, and mutation, finding that recombinant strains and pseudogenes can persist and cause congenital infections.