M. McDew-White

Genomic analysis of a parasite invasion: colonization of the Americas by the blood fluke, Schistosoma mansoni

This study analyzes genomic data from Schistosoma mansoni to determine if there was a population bottleneck during its colonization of the Americas and identifies regions under selection.

Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations

This study shows that fitness costs of antimalarial drug resistance mutations are significantly higher in nutrient-limited media compared to standard RPMI, suggesting underestimation in typical lab conditions.

The hemolymph of Biomphalaria snail vectors of schistosomiasis supports a diverse microbiome

The paper analyzes the microbiome of Biomphalaria snail hemolymph to understand its composition and potential role in schistosomiasis transmission.

Striking differences in virulence, transmission, and sporocyst growth dynamics between two schistosome populations

This study compares two Schistosoma mansoni populations, finding significant differences in virulence, transmission, and sporocyst growth dynamics between them.

The extended recovery ring stage survival assay provides superior prediction of patient clearance half life and increases throughput

The paper introduces an improved ring-stage survival assay (eRRSA) that better predicts patient clearance half-life and increases throughput for artemisinin resistance testing.

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

The paper identifies widespread oxamniquine resistance alleles in Old World Schistosoma mansoni populations, showing they predate drug use and exist as standing genetic variation.

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites

The paper identifies an ancient introgression event between Schistosoma haematobium and S. bovis, with adaptive selection on an invadolysin gene.

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

The paper identifies genetic determinants of Plasmodium falciparum fitness across its life cycle using bulk segregant analysis and experimental crosses.

Mode and tempo of microsatellite length change in a malaria parasite mutation accumulation experiment

This study quantifies microsatellite mutation rates in malaria parasites, finding low rates influenced by repeat motif and array length, with most mutations involving multiple repeat changes.