R. P. de Vries

Asymmetrical Bi-antennary Glycans Prepared by a Stop-and-Go Strategy Reveal Receptor Binding Evolution of Human Influenza A Viruses

This paper develops a stop-and-go chemoenzymatic method to synthesize asymmetrical bi-antennary glycans and uses them to study receptor binding evolution of human influenza A viruses.

Bioluminescent detection of viral surface proteins using branched multivalent protein switches

This paper introduces a modular bioluminescent sensor platform (dark-LUX) for detecting viral surface proteins using multivalent binding domains and NanoBiT technology, demonstrating its application with influenza A virus proteins.

Exploiting Substrate Specificities of 6-O-Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides

This paper uses sulfotransferase substrate specificities to enzymatically synthesize keratan sulfate oligosaccharides and investigates their binding properties with lectins and viral proteins.

Probing Altered Receptor Specificities of Antigenically Drifting Human H3N2 Viruses by Chemoenzymatic Synthesis, NMR and Modeling

The paper examines altered receptor specificities of H3N2 influenza viruses using NMR and computational methods to identify binding interactions with extended N-glycans.

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection

This study shows that recent H3N2 influenza A viruses require a low threshold of glycan receptors for efficient infection, and increasing receptor numbers beyond this threshold does not improve infection efficiency.

Genome evolution and transcriptome plasticity associated with adaptation to monocot and eudicot plants in Colletotrichum fungi

This study analyzes genome and transcriptome data from 30 Colletotrichum species to show evolutionary adaptations to monocot and eudicot hosts, including gene expansion and expression changes.

3D visualization of SARS-CoV-2 infection and receptor distribution in Syrian hamster lung lobes display distinct spatial arrangements

The paper uses 3D visualization to show that SARS-CoV-2 infection in Syrian hamster lungs occurs only where ACE2 and TMPRSS2 co-localize.

Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

The paper functionally and antigenically characterizes the hemagglutinin and neuraminidase of Wuhan spiny eel influenza virus to assess its status as a bona fide influenza virus.

Glycan remodeled erythrocytes facilitate antigenic characterizationof recent A/H3N2 influenza viruses

The paper demonstrates that glycan remodeling of erythrocytes enables antigenic characterization of recent A/H3N2 influenza viruses that lack agglutination ability.

Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2

This study identifies heparan sulfate proteoglycans as an attachment factor for SARS-CoV-2 and suggests HS oligosaccharides could inhibit viral binding.

The Intestinal Microbiota Contributes To The Control Of Highly Pathogenic H5N9 Influenza Virus Replication In Ducks

This study shows that the intestinal microbiota in ducks modulates antiviral immune responses, reducing H5N9 influenza virus replication in the intestine but not in other tissues.