Author

M. N. Sheppard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

A. Asimaki· 1 shared A. Barnes· 1 shared A. Clerk· 1 shared A. Tafuni· 1 shared C. Bueno-Beti· 1 shared C. F. McTiernan· 1 shared D. N. Meijles· 1 shared E. Field· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPathology

A. Asimaki

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy

C. Bueno-Beti, A. Tafuni, S. P. Chelko, M. N. Sheppard, E. Field, J. Tollit, I. K. Heenan, A. Barnes, M. R. Taylor, L. Mestroni, J. P. Kaski, J. E. Saffitz, A. Asimaki

This study finds persistent NFκB signaling in cardiac myocytes and increased CCR2-expressing cells in arrhythmogenic cardiomyopathy patients, with similar findings in buccal mucosa cells from young subjects with disease alleles.

bioRxiv · Jul 25, 2023 · PreprintPathology

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

bioRxiv · Aug 14, 2021Biochemistry