M. R. Taylor

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

This study shows IL-1β disrupts BBB development by inhibiting endothelial Wnt/β-catenin signaling in zebrafish.

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy

This study finds persistent NFκB signaling in cardiac myocytes and increased CCR2-expressing cells in arrhythmogenic cardiomyopathy patients, with similar findings in buccal mucosa cells from young subjects with disease alleles.

Histone divergence in Trypanosoma brucei results in unique alterations to nucleosome structure

This study characterizes the structure of nucleosome core particles from Trypanosoma brucei, revealing unique histone alterations that affect DNA and protein interactions.

Vancomycin Relieves Mycophenolate Mofetil-Induced Gastrointestinal Toxicity by Eliminating Gut Bacterial β-Glucuronidase Activity

This study shows vancomycin reduces MMF-induced GI toxicity by inhibiting gut bacterial β-glucuronidase activity, preventing MPA conversion from its glucuronidated form.