J. D. Estes

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

An in situ quantitative map of initial human colorectal HIV transmission

This study quantifies HIV transmission dynamics in human colorectal tissue, showing HIV localizes to mucosal dendritic cells and submucosal macrophages rather than CD4+ T-cells.

Virus-Dependent Immune Conditioning of Tissue Microenvironments

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence

The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.