Author

M. Martin-Sandoval

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. J. DeBerardinis· 3 shared T. P. Mathews· 3 shared W. Gu· 3 shared C. Yang· 2 shared D. Bezwada· 2 shared D. Do· 2 shared F. Cai· 2 shared H. S. Vu· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

R. J. DeBerardinis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Electron transport inhibition increases cellular dependence on purine transport and salvage

Z. Wu, D. Bezwada, R. C. Harris, C. Pan, P. T. Nguyen, B. Faubert, L. Cai, F. Cai, H. S. Vu, H. Chen, M. Martin-Sandoval, D. Do, W. Gu, Y. Zhang, B. Ko, , R. J. DeBerardinis

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

bioRxiv · May 11, 2023Biochemistry

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

F. Cai, D. J. Bezwada, L. Cai, R. Mahar, Z. Wu, P. Pachnis, C. Yang, S. Kelekar, W. Gu, H. S. Vu, T. P. Mathews, L. G. Zacharias, M. Martin-Sandoval, D. Do, K. C. Oaxaca, , R. J. DeBerardinis

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

bioRxiv · Jul 31, 2022Biochemistry

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

A. B. Aurora, V. Khivansara, A. Leach, J. G. Gill, M. Martin-Sandoval, C. Yang, S. Y. Kastininon, D. Bezwada, A. Tasdogan, W. Gu, T. P. Mathews, Z. Zhao, R. J. DeBerardinis, S. J. Morrison

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

bioRxiv · Nov 11, 2021 · PreprintCancer Biology

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

W. Wang, A. DeVilbiss, M. Arreola, T. Mathews, Z. Zhao, M. Martin-Sandoval, G. Benegiamo, A. Awani, L. Goeminne, D. Dever, Y. Nakauchi, M. Pavel-Dinu, W. Al-Herz, L. Noratangelo, M. H. Porteus, , K. G. Weinacht

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

bioRxiv · Jul 5, 2021 · PreprintCell Biology